However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Other less frequently occurring events include: Side Effect: Silver Sulfadiazine's possible side effects include: In lactating or pregnant females, use with caution. Never use this medication for animals allergic to sulfite drugs or this medication. It is for use on skin only do not put in or around your pet's eyes. Silver Sulfadiazine Cream 1% should not be used on animals who are allergic to sulfur or sulfa drugs, or on pregnant or nursing animals. Silver Sulfadiazine Cream 1% Dosage for Horses Silver Sulfadiazine Cream 1% Dosage for Dogs However, do not continue application longer than directed. Continue to apply cream to your pet for as long as you've been directed to by your veterinarian even if your pet's burn appears to have greatly improved. For reference, a penny is approximately 1/16th of an inch thick. Silver Sulfadiazine Cream 1% Dosage for Catsįollowing your veterinarian's directions, apply enough cream to cover the burn wounds in a layer about 1/16th of an inch thick. Wear sterile gloves while applying, and apply only to cleaned areas. Give this medication exactly as directed by your veterinarian. Tip: Silver Sulfadiazine Cream 1% is for topical use only. Always reapply cream if your pet bathes or gets wet. It is important that your pet's burn be covered with the cream at all times, so if the cream rubs off on a bandage, your pet's bedding or other cloth, you may need to reapply the cream. After application, you may leave the wound uncovered, or cover it with a sterile gauze bandage. Apply the cream once or twice a day, as directed.This is to avoid introducing additional bacteria and other infective agents into the burned area of your pet's skin. Once your pet's wound is clean, wash your hands thoroughly again and put on sterile disposable gloves. Before treating your pet with Silver Sulfadiazine Cream 1%, wash your hands and then clean the affected area of your pet's skin as directed by your veterinarian. Silver Sulfadiazine Cream 1% is a prescription antibacterial medication that is used topically on burns to prevent and treat bacterial and yeast infections.Ĭomparison of silver sulfadiazine 1% with chlorhexidine digluconate 0.2% to silver sulfadiazine 1% alone in the prophylactic topical antibacterial treatment of burns. Ĭomparison of silver sulphadiazine 1 per cent, silver sulphadiazine 1 % plus chlorhexidine digluconate 0.2 per cent and mafenide acetate 8.5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds. Ī Randomized Prospective Study of Topical Antimicrobial Agents on Skin Grafts After Thermal Injury. In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate. the myeloid depression is typically reversable expect when a profound thrombocytopenia accompanies the neutropeniaĬomparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. granulocytopenia typically occurs within the first 5 days after injury note possible depression myeloid elements in blood and resistance exhibited by certain gram negative bacteria accumulation of the drug may occur in patients with impaired renal or hepatic function ? aspirin is a good screening drug for G6P deficiency use w/ caution in patients with G6P defficiency (increased risk of hemolysis) dosage: apply qd to bid to burn area (dressings not required over burn area) note: resistance to silvadene is mediated by plasmids which may also confer resistance to other antibiotics nearly all enterobacter and pseudomonas will develop resistance thus, it is relatively ineffective in controlling bacterial proliferation in the eschar once high bacterial densities have occurred silver sulfadiazine is poorly soluble and has only limited ability to penetrate into the burn wound silver sulfadiazine is painless on application (and is often soothing) and causes no acid base abnormalities topical bactercidal agent effective against many gran negative and positive bacteria as well as yeast, however, is absorbed poorly through the eschar site, and is ineffective against enterobacter and pseudomonas for prevention and treatment of wound sepsis in patients with second and third degree burns silvadene burn cream is a 1% suspension of silver sulfadiazine in a water soluble base
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